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NMR Metabolomics and Chemometrics of Lettuce, Lactuca sativa L., under Different Foliar Organic Fertilization Treatments

Virginia Lanzotti, Attilio Anzano, Laura Grauso, Maurizio Zotti, Adriana Sacco, Mauro Senatore, Mauro Moreno, Marcello Diano, Maddalena Parente, Serena Esposito, Pasquale Termolino, Emanuela Palomba, Astolfo Zoina and Stefano Mazzoleni Lettuce plants were grown in a greenhouse affected by the fungal pathogen Fusarium oxysporum to test the effects on plant metabolomics by different organic treatments. Three foliar application […]

Effects of Extracellular Self- and Nonself-DNA on the Freshwater Microalga Chlamydomonas reinhardtii and on the Marine Microalga Nannochloropsis gaditana

Emanuela Palomnba, Pasquale Chiaiese, Pasquale Termolino, Rosa Paparo, Edgardo Filippone, Stefano Mazzoleni and Maria Luisa Chiusano The role of extracellular DNA (exDNA) in soil and aquatic environments was mainly discussed in terms of source of mineral nutrients and of genetic material for horizontal gene transfer. Recently, the self-exDNA (conspecific) has been shown to have an […]

Self-DNA Exposure Induces Developmental Defects and Germline DNA Damage Response in Caenorhabditis elegans

Marcello Germoglio, Adele Adamo, Guido Incerti, Fabrizio Cartenì, Silvia Gigliotti, Aurora Storlazzi, and Stefano Mazzoleni All organisms, from bacteria to mammals, sense and respond to foreign nucleic acids to fight infections in order to survive and preserve genome integrity across generations. The innate immune system is an evolutionarily conserved defence strategy. Complex organisms have developed […]

Arabidopsis thaliana Response to Extracellular DNA: Self Versus Nonself Exposure

Chiusano, Maria Luisa, Guido Incerti, Chiara Colantuono, Pasquale Termolino, Emanuela Palomba, Francesco Monticolo, Giovanna Benvenuto, Alessandro Foscari, Alfonso Esposito, Lucia Marti, Giulia de Lorenzo ,Isaac Vega-Muñoz, Martin Heil, Fabrizio Carteni, Giuliano Bonanomi and Stefano Mazzoleni The inhibitory effect of extracellular DNA (exDNA) on the growth of conspecific individuals was demonstrated in different kingdoms. In plants, […]

The Role of DNA in the Extracellular Environment: A Focus on NETs, RETs and Biofilms

Francesco Monticolo, Emanuela Palomba, Pasquale Termolino, Pasquale Chiaiese, Elisabetta de Alteriis, Stefano Mazzoleni, Maria Luisa Chiusano The capacity to actively release genetic material into the extracellular environment has been reported for bacteria, archaea, fungi, and in general, for microbial communities, but it is also described in the context of multicellular organisms, animals and plants. This […]

Self-DNA inhibitory effects: Underlying mechanisms and ecological implications

Fabrizio Cartenì, Giuliano Bonanomi, Francesco Giannino, Guido Incerti, Christian Ernest Vincenot, Maria Luisa Chiusano, and Stefano Mazzoleni DNA is usually known as the molecule that carries the instructions necessary for cell functioning and genetic inheritance. A recent discovery reported a new functional role for extracellular DNA. After fragmentation, either by natural or artificial decomposition, small […]

New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems

Stefano Mazzoleni, Fabrizio Cartenì, Giuliano Bonanomi, Guido Incerti, Maria Luisa Chiusano, Pasquale Termolino, Antonello Migliozzi, Mauro Senatore, Francesco Giannino, Max Rietkerk, Antonio Risitano & Virginia Lanzotti The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based […]